Biodiversity Biodiversity and Application of Biotechnology in Agriculture

Head of the laboratory's speech

Welcome to the official website of the "Biodiversity and Application of Biotechnology in Agriculture" (BABDA) research laboratory — a newly established research unit within our faculty, created to address the growing need for scientific support in advancing the agricultural sector in our region.

The establishment of this lab is driven by multiple essential reasons, including the urgent demand for applied scientific research to develop agriculture both in quantity and quality. It also provides a stimulating environment for academic staff and postgraduate students to conduct research, especially given the lack of PhD programs within our faculty due to the absence of research laboratories. BABDA aims to enable participation in national research projects such as PRFU, and foster collaboration with socio-economic partners and research institutions at both the national and international levels.

Laboratory objectives

The BABDA laboratory focuses its scientific research on addressing environmental and agricultural challenges specific to the local ecosystem, such as soil types and water permeability issues. This includes the application of hydrogels to enhance soil quality. Furthermore, the lab emphasizes the valorization of local biodiversity and the chemo-diversity of plant products with pharmacological and nutritional properties. It also aims to apply modern biotechnological methods to improve the yield and quality of agricultural products for use in various life domains. A major research goal is the synthesis of new heterocyclic compounds with biological significance.

PR.Ahmed Elkhalifa CHEMSA

Director of: Biodiversity and Application of Biotechnology in Agriculture

The human composition of the laboratory

Research team : 01 :Engineering of Biological and Agricultural Systems
Institution	Email	Specialization	Last Degree	Position	Rank	Name and Surname	No.
University of El Oued	[email protected]	Agricultural Sciences	Professorship	President	Full Professor	Nili Mohamed Es-Saghir	01
University of El Oued		Agricultural Sciences	University Qualification	Member	Assistant Professor "A"	Zaatar Abdelmalek	02
University of El Oued		Agricultural Sciences	University Qualification	Member	Assistant Professor "A"	Mahfoud Babaou Ismail	03
General Objective: The team aims to address critical socio-economic issues in the region with potential national applications. This includes: assessing the impact of industrial activity on the quality of life in Touggourt, reducing water usage in agriculture using hydrogel, lowering energy costs, and raising awareness among farmers about scientific research Scientific Themes: Reducing water overuse in sandy soils using hydrogel Studying the environmental impact of industrial activities Promoting hydrogel use in arid and semi-arid regions						Research Topics

Research Team : 02Biotransformation of Agricultural Products with Nutritional and Health Interest
Institution	Email	Specialization	Last Degree	Position	Rank	Name and Surname	No.
University of El Oued		Biochemistry	Professorship	President	Full Professor	Drouiche Samir	01
جامعة باتنة		Biochemistry	University Qualification	Member	Assistant Professor "A"	Fattani Samir	02
University of El Oued		Veterinary	PhD	Member	Assistant Professor "B"	Bakouche Amal	03
University of El Oued		Biochemistry	PhD		Assistant Professor "B"	Zghib Khawla	4
M.A.F.S. El Oued		Biochemistry	PhD		Assistant Professor "B"	Alayeb Ibtissem	5
General Objective: The objective of this research unit is to study the biotransformation of agricultural products and to apply biological substances extracted from various sources (plant, animal, microbial, or mineral) in fields such as nutrition, food industry, pharmaceuticals, and cosmetics. Another goal is to valorize agricultural by-products to produce high-value products Scientific Themes: Studying the effect of biotransformation on the nutritional value of agricultural products Studying the nutritional value of agricultural products Investigating the nutritional effects of molecules extracted from microorganisms Studying the nutritional quality of food produced from bio-substances Valorization of agricultural by-products						Research Topics

Research Team : 03:Chemistry and Valorization of Plant Products
Institution	Email	Specialization	Last Degree	Position	Rank	Name and Surname	No.
University of El Oued		Plant Biology	Professorship	President	Full Professor	Ahmed Khalifa Shamsa	01
جامعة باتنة		Microbiology	University Qualification	Member	Assistant Professor "A"	Ammar El-Tahami Al-Ayash	02
University of El Oued		Biochemistry	PhD	Member	Assistant Professor "B"	Asma Yembai	03
University of El Oued		Organic Chemistry	PhD	Member	Assistant Professor "B"	Yahi Nemosa El-Tijani	4
M.A.F.S. El Oued		Plant Biology	PhD	Member	Assistant Professor "B"	Nora Graisa	5
University of El Oued		Biology	PhD	Member	Assistant Professor "A"	Said Touati	6
University of El Oued		Plant Biology	PhD	Member	Assistant Professor "A"	Nizar Cherada	7
General Objective: This team focuses on the valorization of agricultural products and the chemical diversity of plant-based natural materials. The studies involve analyzing plant materials traditionally used in folk medicine, examining the biological and toxicological properties of extracts from these plants, and exploring their therapeutic applications. Research and valorization of agricultural products and natural materials and their applications in the food industry Extraction and characterization of natural materials from selected plants Characterization using techniques such as HPLC, MS, NMR in collaboration with phytochemistry laboratories Study of the antibacterial and antiparasitic effects of plant extracts for therapeutic use Biological activities of natural materials Toxicity of medicinal plants and biologically active molecules Detection of toxicity mechanisms and the development of methods for studying toxic effects Cellular studies to evaluate the toxicity and pharmacological properties of plant extracts Evaluation of the animal toxicity of these extracts (mice, rabbits, etc.)						Research Topics

Research Team : 04:Adaptive Biotechnology and Ecological Physiology in Arid Agroecosystems
Institution	Email	Specialization	Last Degree	Position	Rank	Name and Surname	No.
University of El Oued		Agricultural Sciences	Professorship	President	Full Professor	Aseila Ismail	01
University of El Oued		Biology and Animal Ecology	PhD	Member	Assistant Professor "B"	Saadi Hamza	02
University of El Oued		Biochemistry	PhD	Member	Assistant Professor "B"	Majour Abdelkader	03
This unit aims to study the behavior of living organisms (plants, microorganisms...) in arid and semi-arid environments through the use of biotechnological tools and ecological physiology techniques. The focus is on understanding the biological adaptation mechanisms of plants and microbes to harsh conditions (heat, drought, salinity), in order to develop innovative and sustainable agricultural solutions that enhance productivity and preserve natural resources in arid agroecosystems						Research Topics

Research Team : 05:Biodiversity and Valorization of Microorganisms in Agriculture
Institution	Email /Email	Specialization	Last Degree	Position	Rank	Name and Surname	No.
University of El Oued		Environment	University Qualification	President	Assistant Professor "A"	Mhadde Ismail	01
University of El Oued		Agricultural Sciences	University Qualification	Member	Assistant Professor "A"	Merdassi Samir	02
University of El Oued		Environment and Ecosystem	PhD	Member	Assistant Professor "B"	Boufyane Mabrouka	03
The objective of the research conducted by our team is to explore and valorize the biodiversity of microorganisms within the specific context of agriculture. We aim to deeply understand how these microorganisms play a crucial role in improving the health of agricultural soils. Indeed, they are essential for strengthening crop resilience to various stresses, whether biotic (such as diseases and pests) or abiotic (such as drought and salinity) Our approach stands out through the use of innovative methods in environmental microbiology, allowing for precise identification of beneficial microorganisms present in agricultural ecosystems. As part of our research, we also examine the complex interactions between these microorganisms, cultivated plants, and their environment. This includes studying intercellular communication mechanisms, beneficial microbial symbioses, and the impact of these interactions on overall crop health. In parallel, our goal is to develop practical applications from these discoveries to sustainably and ecologically optimize agricultural yields. Main Research Themes Proposed by the Team Exploration of microbial biodiversity Valorization of beneficial microorganisms Microbe-plant interactions Practical applications in agricultural microbiology Ecology of microbial communities in agricultural soils Optimization of agricultural systems through microorganisms Innovation and technology transfer in agricultural microbiology						Research Topics

International Publications

usko, B. M., Johansen, J. R., Mehda, S., Perona, E., & Muñoz-Martín, M. Á. (2024). Four Novel Species of Kastovskya (Coleofasciculaceae, Cyanobacteriota) from Three Continents with a Taxonomic Revision of Symplocastrum. Diversity, 16(8), 474.

Oustani, M., Mehda, S., Youcef, F., Halilat, M. T., Cheloufi, H., Messadia, H., & Chenchouni, H. (2024). Organic carbon and nitrogen mineralization under saline conditions of dry hot arid lands: an incubation experiment. Euro-Mediterranean Journal for Environmental Integration, 1-12.

Mehda Smail, Oustani Mabrouka, Bouazza, S., & Djaballah, I. (2023). Effect of sowing dates on the vegetative growth and yield parameters of two quinoa (Chenopodium quinoa Willd.) genotypes. Journal of Agriculture and Applied Biology, 4(1), 95-106.

Oustani Mabrouka, Mehda Smail, Halilat Mohammed Tahar, & Chenchouni Haroun. (2023). Yield, growth development and grain characteristics of seven Quinoa (Chenopodium quinoa Willd.) genotypes grown in open-field production systems under hot-arid climatic conditions. Scientific Reports, 13(1), 1991.

Mehda Smail, Muñoz-Martín Maria Ángeles, Oustani Mabrouka, Hamdi-Aïssa Baelhadj, Perona Elvira, & Mateo Pilar (2022). Lithic cyanobacterial communities in the polyextreme Sahara Desert: Implications for the search for the limits of life. Environmental Microbiology, 24(1), 451-474.

Oustani Mabrouka, Tadjine Farida, & Mehda Smail. (2022). Use of Solar Energy in the Sustainable Development of Agriculture in the Saharan Regions of Algeria. In Sustainable Energy-Water-Environment Nexus in Deserts (pp. 675-680). Springer, Cham.

Mabrouka Oustani, Mehda Smail & Halilat Mohammed Tahar. (2021). Valorization of Oasis Wastes by Composting Procedure under Hot Arid Conditions of Algerian Saharan Regions. Annals of the Romanian Society for Cell Biology, 25(6), 20976-20994.

MEHDA Smail, Muñoz-Martín Maria Ángeles, Oustani Mabrouka, Hamdi-Aïssa Baelhadj, Perona Elvira, & Mateo Pilar. (2021) Microenvironmental Conditions Drive the Differential Cyanobacterial Community Composition of Biocrusts from the Sahara Desert. Microorganisms, 2021, vol. 9, no 3, p. 487.

Geographical location and cultivar‐linked changes on chemical properties of olive oils from Algeria. Food Science & Nutrition 10 (6), 1937-1949.

KADRI, M., YAHIA, A., GOUBI, S., MEKHEDMI, N. E., SELMANE, M., & CHEMSA, A. E. (2022). Chromatography analysis, in vitro antioxidant and antibacterial activities of essential oil of Artemisia herba-alba Asso of Boussaâda, Algeria. Biodiversitas Journal of Biological Diversity, 23(9).

Kaddour, A., Amara, D. G., Moussaoui, Y., Chemsa, A. E., Alia, Z., & Kamarchou, A. (2022). Total phenolic and flavonoid contents of Mentha spicata leaves aqueous extracts in different regions of Algeria and their antioxidant, and antidiabetic activities. Tropical Journal of Pharmaceutical Research, 21(9), 1907-1913.

Gheraissa, N., Chemsa, A. E., Elsharkawy, E., & Cherrada, N. (2022). Phenolic compound profile, and evaluation of biological properties of Bassia muricata (L.) Asch. aerial part. International Journal of Secondary Metabolite, Vol. 9, No. 3, 335-347. https://doi.org/10.21448/ijsm.1080537

Gheraissa, N., Chemsa, A. E., Cherrada, N., Erol, E., Elsharkawy, E. R., Ghemam-Amara, D., … & AbdelKader, M. S. (2023). Biochemical Profile and In Vitro Therapeutic Properties of Two Euhalophytes, Halocnemum strobilaceum Pall. and Suaeda fruticosa (L.) Forske., Grown in the Sabkha Ecosystem in the Algerian Sahara. Molecules, 28(8), 3580. https://doi.org/10.3390/molecules28083580

Cherrada, N., Chemsa, A. E., Gheraissa, N., Djilani, G. A., El Manawaty, M. A., Rebiai, A., …. & Awuchi, C. G. (2023). Antioxidant potentials and inhibitory activities of α-amylase, α-glucosidase, and acetylcholinesterase of different fractions from Salsola tetragona Delile. International Journal of Food Properties, 26(1), 1787-1796. https://doi.org/10.1080/10942912.2023.2230385

Cherrada, N., Chemsa, A. E., Erol, E., Akyildiz, A. G., Dinc, H. O., Gheraissa, N., … & Messaoudi, M. (2023). Phytochemical profiling of Salsola tetragona Delile by LC-HR/MS and investigation of the antioxidant, anti-inflammatory, cytotoxic, antibacterial and anti-SARS-CoV-2 activities. Saudi Pharmaceutical, 31(9), 101731. https://doi.org/10.1016/j.jsps.2023.101731

Gheraissa, N., Chemsa, A. E., Cherrada, N., Ebru, E., & Elsharkawy, E. R. (2023). Anabasis oropediorum Maire. as a health-promoting source: Phytochemical content, in vitro antioxidant, antidiabetic, antibacterial, and anti-inflammatory potential. JOURNAL OF RESEARCH IN PHARMACY, 27(5). https://doi.org/10.29228/jrp.474

Benamor, B., Gheraissa, N., Djellab, K., Haddad, A. A., Retim, L., Cherrada, N., Chemsa, A. E., (2023) Chala, A. Exploring the biochemical potential of male date palm (phoenix dactylifera L.) leaflets from Biskra region, Algeria: a comprehensive analysis of flavonoids, phenols, proteins, and carbohydrates. NeuroQuantology, 21(7),121-130. https://doi.org/10.48047/nq.2023.21.7.nq23014

Tedjani, A., Boual, Z., Telli, A., Chemsa, A. E., & Khelef, Y. (2023). Ethnobotanical survey of two astragalus species used by the local population in El-Oued province (septentrional Algerian Sahara). Vegetos, 1-11. https://doi.org/10.1007/s42535-023-00755-6

AMARA, D. G., LAOUEDJ, H., CHEMSA, A. E., & BOUGRINAT, H. (2023). Citrullus lanatus plant response to irrigation water magnetized in sandy soil. Journal of Medicinal Plants Research, 17(5), 129-136. https://academicjournals.org/journal/JMPR/article-full-text-pdf/49BF0C470683

Kaddour, A., Chemsa, A. E., Laouedj, H., Amara, D. G., Moussaoui, Y., Cherrada, N., & Zaater, A. (2023). Biological activities of Mentha spicata L. extracts growing in different geographical regions of Algeria. Acta Periodica Technologica(54), 177-186. https://doi.org/10.2298/APT2354177K

Bachir Hamidi, Djilani Ghemam Amara, Zaid Alia, Ahmed Elkhalifa Chemsa, Chafika Rezkallah, Messoudi Mohammed, Mokded Rabhi (2023) Cynanchum Acutum L: Phytochemical Screening, Allelopathic and Cyto/Genotoxicity Effects in the Plant Model Arachis Hypogaea. Gradiva, 62(8) 143-156.

BENAMOR, Bilal, Noura GHERAISSA, Khanssa DJELLAB, Amel Abir HADDAD, Linda RETIM, Nezar CHERRADA, Ahmed Elkhalifa CHEMSA, and Adel CHALA. “EXPLORING THE BIOCHEMICAL POTENTIAL OF MALE DATE PALM (Phoenix dactylifera L.) LEAFLETS FROM BISKRA REGION, ALGERIA: A COMPREHENSIVE ANALYSIS OF FLAVONOIDS, PHENOLS, PROTEINS, AND CARBOHYDRATES.” NeuroQuantology 21, no. 7 (2023): 121.

Nezar Cherrada, Ahmed Elkhalifa Chemsa, Noura Gheraissa, Abdelmalek Zaater, Bilal Benamor, Ahmed Ghania, Bouras Yassine, Abdelbasset Kaddour, Muhammad Afzaal, Aasma Asghar, Farhan Saeed & Degnet Teferi Asres (2024) Antidiabetic medicinal plants from the Chenopodiaceae family: a comprehensive overview, International Journal of Food Properties, 27:1, 194-213, DOI: 10.1080/10942912.2023.2301576

Noura Gheraissa, Ahmed Elkhalifa Chemsa, Nezar Cherrada, Bilal Benamor, Ebru Erol, Eman Ramadan Elsharkawy, Bouras Yassine, Mohammed Messaoudi, Ayomide Victor Atoki (2024) Exploring the phytochemical and biological properties of Salsola foetida: a promising wild plant from Southeastern Algeria. International Journal of Food Properties, 27:1, 584-601 DOI: 10.1080/10942912.2024.2339248

Bilal BENAMOR, Kaouthar GHENBAZI, Meriem BERRAMDANE, Noura GHERAISSA, Linda RETIMA, Nezar CHERRADA, Ahmed Elkhalifa CHEMSA, Djilani GHEMAM AMARA, Adel CHALA (2024) Chemical profiling of male date palm (Phoenix dactylifera L.) leaflets in El M’Ghair region, Algeria: Insights into total phenols, flavonoids, proteins, and total sugars. Acta agriculturae Slovenica. 120:1, 1-8, DOI: 10.14720/aas.2024.120.1.16578

Dina Raouane Zellagui, Ahmed el Khalifa Chemsa, Widad Hadjab, Youcef Halis, Mehmet Ozturk, Saber Boutellaa, Amar Zellagui, Noureddine Gherraf (2024) Chemical composition, antibacterial, antioxidant, and anticholinesterase activities, in vitro and in silico, of the essential oil of Algerian endemic species Daucus biseriatus Murb. International Journal of Environmental Health Research. doi.org/10.1080/09603123.2024.2444377

Nezar Cherrada, Ahmed Elkhalifa Chemsa, Noura Gheraissa, Ibtissam Laib, Zakia Gueboudji, Mohamed EL‐Shazly, Abdelmalek Zaater, Asma Abid, Sherouk Hussein Sweilam, Talha Bin Emran, Sadok Nani, Bilal Benamor, Djilani Ghemam Amara, Ayomide Victor Atoki, Mohammed Messaoudi (2024) Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers. Food Science & Nutrition. 12(11) 8793-8824. doi.org/10.1002/fsn3.4536

Yassine Bouras, Chouikh Atef, Nezar Cherrada, Noura Gheraissa, Djihad Chenna, Ahmed Elkhalifa Chemsa, Hadia Hemmami, Ayomide Victor Atoki, Barbara Sawicka, Maria Atanassova, Sheikh F Ahmad, Sabry M Attia, Mohammed Messaoudi (2024) Phytochemical profile and biological activities of Brassica oleracea var. elongata leaf and seed extracts: An in vitro study. Italian Journal of Food Science. 36(4) doi.org/10.15586/ijfs.v36i4.2691

Boulaares Islam, Derouiche Samir. Effect of Garlic and Onions Extract Enriched with Honey Treatment on the Lipid Profile, Biochemical and Hematological Biomarker Status in Healthy

Women. Pharmaceutical and Biosciences Journal Vol. 9(1), 22-27, 2021.

Atoussi Ouidad, Chetehouna Sara, Boulaares Islam, Guemari Imane Yousra, Derouiche

Samir. Analysis of Blood Pressure, Lipid Profile and Hematological Biomarkers in men Addicted to Tobacco Chewing. Research Journal of Pharmacology and Pharmacodynamics.

13(1): January – March, 2021.

: Samir, D., Saadia, S., & Maroua, L.. Identification and assessment of Modifiable and NonModifiable risk factors and oxidative stress in pathophysiology of stroke diseases- a

review. Journal of Progressive Research in Biology, 5(1), 1-11 (2021).

Samir, Derouiche, and Kaouachi Aicha. “Protective effect of zinc and Pine barks extract supplement against Indometacin-induced gastric ulcer in rats.” Acta Scientifica Naturalis 8.1

(2021): 1-14.

Achchi, Ikram, and Samir Derouiche. “Study of the effect of obesity on immune cells activity and cardiovascular disease risk in el-oued (algeria) women.” innovare journal of

medical sciences (2021): 28-30.

Chouia Maroua, Hammadi Nour, Derouiche Samir. “Prevalence and Epidemiological Study of hepatitis B and C patients admitted to BEN AMOR DJILANI hospital in El Oued,

Algeria.” Pharmaceutical and Biosciences Journal (2021): 41-48.

Derouiche Samir, Ahmouda Ibtissam and Moussaoui Rokaya. Effectiveness of a Novel SeNPs synthetized by Aquilaria malaccensis extract compared to selenium acetate on lead induced metabolic disorder and oxidative stress in pregnant rats. International Journal of

Chemical and Biochemical Sciences. 19(2021): 50-57.

Samir, Derouiche, Haddig Nour El-houda, and Zerzour Aicha. “Hematological and Oxidative Stress Markers Analysis for Detection and Prediction of Osteoporosis in Post-

menopausal Women.World Journal of Environmental Biosciences 10.2 (2021): 30-36.

Ibtissam Laieb, Samir Derouiche and Wiam Z. Aristolochia longa (Aristolochiaceae) Spice Alleviates Nickel-Induced Oxidative Stress and Biochemical Alterations in Rats. Austin J

Pharmacol Ther. 2021; 9(6).1151.

Sara Chetehouna, Ouidad Atoussi, Samir Derouiche. An overview of Portulaca oleracea:

Phytochemistry and pharmacological activities. International Journal of Pharmacognosy and Clinical Research. 2021; 3(1): 15-18.

Anfal Djouadi and Derouiche Samir. Spinach mediated synthesis of zinc oxide

nanoparticles: charachterization, invitro biological activities stydy and invivo acute toxicity evaluation. Current research in green and sustainable chemistry. 4 (2021): 100214

Anfal Djouadi and Samir Derouiche. In-vivo Antioxidant activity of spinacia oleracea in fluoride induced biochemical disorder and renal oxidative stress in wistar rats. Plant Cell

Biotechnology and Molecular Biology 23(21&22):80-88; 2022

Anfal Djouadi, Samir Derouiche. Assessment of Hematological Profile and Oxidative Stress Status in Sodium Fluoride Induced Anemia and Kidney Disorder in Rats. Current Trends in

Biotechnology and Pharmacy. (2022) 16 (3) 365 – 372.

Anfal Djouadi, Samir Derouiche. Influence of high fluoride in drinking water on some biological and histological markers in rats. Advances in Food Sciences. (2022) 44(3): 79-83

Zaater abdelmalek, Derouiche samir, Lassoued Chaima, Belekrem Chaima .Prevalence and cardiovascular risk of self-medication in urban area of Tebessa (Algeria) population. Journal

of Cardiovascular Disease Research. 2022; 13(7):420-428

Anfal Djouadi, Samir Derouiche. Beneficial effect of SPE-ZnO nanoparticles against hepatorenal toxicity and oxidative stress induced by fluoride in wistar rats. Biochem. Cell.

Arch. 2022; 22(2): 4047-4054.

Derouiche Samir, Salem Saadia and Leguemairi Maroua Study of Risk Factors and Assessment of Hematotoxicity and Oxidative Stress Among Women Stroke Patient with

Metabolic Syndrome. Dhaka Univ. J. Pharm. Sci. 21(2): 193-201, 2022.

Derouiche Samir, Chetehouna Sara, Atoussi Ouidad, Guemari Imane Yousra. Phytochemicals content, ICP-OES metals determination and protective effect of

consumption of dates robe on anemia disease risk in healthy women. Algerian journal of arid environment, 2022; 12(1): 4-14.

Samir Derouiche, Achouak Kenioua, Khadidja Benoune. Characterization of natural extracted green clay and study of its effect against lead toxicity in rats. Fresenius Environmental Bulletin. 31(11): 10934-10941

Chetehouna Sara, Derouiche Samir, Atoussi Ouidad, Guemari Imane-Yousra. Physico- chemical Analysis, Phytochemical content and Antioxidant properties of honey dates “Robe” of some Algeria date variety from Oued Righ and Oued Souf regions. Asian J. Research Chem. 2022; 15(6):399-403.

Derouiche Samir1,2*, Ahmouda Ibtissam1, Moussaoui Rokaya. Study of the toxic effect of drinking water contaminated with lead on liver and kidney functions in pregnant rats: the benefic role of aquilaria malaccensis l. spice. MJBMB, 2022; 2: 43 – 51

Samir D, Saadia S, Maroua L. Assessment of Hematological and Electrolytes Levels and Oxidative Stress Predictive Factors by Logistic Regression Analysis of Acute Ischemic Stroke

Disease. Pharmaceutical and Biomedical Research. 2022; 8(4):323-332.

Derouiche Samir, Bouchoul Serin, Bouchoul Manal, Bya Lina, Abdemalek Djoumana Eco- friendly Phytosynthesis of Copper Nanoparticles Using Medicgo sativa Extract: A Biological Acticity and Acute Toxicity Evaluation. World J Environ Biosci, 2022, 11, 4: 9-15.

Samir Derouiche, Khadidja Benoune, and Achouak Kenioua Influence of Red Clay Minerals on Lead-induced Liver and Testicular Oxidative Stress and Histological Alteration in Rats. Journal of Mining & Environment. https://doi.org/10.22044/jme.2023.12286.2229

Sara Chetehouna, Samir Derouiche, Yassine Réggami. Green synthesis of SeNPs using Sonchus maritimus based nanosized metal oxides for in vitro biological applications and in vivo acute toxicity evaluation. Kragujevac J. Sci. 45 (2023)

Chetehouna S, Derouiche S, Reggami Y, Boulaares I. Sonchus maritimus Extract-Loaded Niosomes Bioconjugated by Linoleic Acid in Hepatic Encephalopathy Induced by High-

Fructose Diet in Albino Wistar Rats. Archives of Razi Institute. 2024;79(1):194-205. DOI: 10.32592/ARI.2024.79.1.194

Sara Chetehouna, Samir Derouiche, Ouidad Atoussi. Identification of New Alkaloids from Algerian Purslane by HPLC-QTOF-MS and Beneficial Effect of Purslane Enriched with Zinc on Experimental Alzheimer Disease in Rats. Current Trends in Biotechnology and Pharmacy

2024; 18(1): 1595-1607. DOI: 10.5530/ctbp.2024.1.8.

Islam Boulaares, Samir Derouiche, Janetta Niemann. HPLC-Q-TOF-MS analysis of phenolic compounds, in vitro biological activities and in vivo acute toxicity evaluation of Ocimum Basilicum L. Fresenius Environmental Bulletin. 2024; 33(2): 73-82

Sara Chetehounaa, Samir Derouichec, Islam Boulaaresc, Yassine Réggamie. Phytochemical profile, anti-inflammatory analysis and cytotoxic activity of SmE-SeNPs against breast (MCF-7) cancer cells. Biocatalysis and Agricultural Biotechnology. 2024; 57: 103122.

Islam Boulaares, Samir Derouiche, Janetta Niemann. Ocimum basilicum L.: A Systematic Review on Pharmacological Actions and Molecular Docking Studies for Anticancer Properties. J Biochem Technol (2024) 15(1): 12-18

Chetehouna S, Derouiche S, Réggami Y, Boulaares Islam , Frahtia A. Gas Chromatography Analysis,

Mineral Contents and Anti-inflammatory Activity of Sonchus maritimus. Trop J Nat Prod Res, 2024; 8(4):6787-6798

Boulaares Islam, Derouiche Samir, Guemari Imane Yousra. Protective effect of ObE against

Doxorubicin-Induced immunosuppression and Cardiotoxicity in Rats. Research J. Pharm. and Tech. 2024; 17(4):1839-1843

Chetehouna S, Derouiche S, Réggami Y. (2024). In Vitro Antioxidant and Antidiabetic properties of

leaves aqueous extract of Sonchus maritimus, Int J Chem Biochem Sci. 25(19): 1-8

Smail Acila , Samir Derouiche & NoraAllioui. Embryo growth alteration and oxidative stress responses in germinating Cucurbita pepo seeds exposed to cadmium and copper toxicity. Scientifc

Reports | (2024) 14:8608 | https://doi.org/10.1038/s41598-024-58635-1.

Boulaares I, Derouiche S, Guemari IY, Impact of Doxorubicin Chemotherapy on Oxidative Stress

Status in Heart and Liver: An experimental Study on Rats. Pharma Sci Analytical Res J 2024; 6(3): 180067.

Chetehouna S, Derouiche S, Boulaares I, Reggami Y. Study of High-Fructose Diet Induced Metabolic

Syndrome: An Experimental Study on Rats. Pharma Sci Analytical Res J 2024, 6(3): 180068.

Chetehouna S, Boulaares I, Atoussi O, Guemari IY, Derouiche S. Green Nanoparticles as a Novel Application of Nanotechnology in Medicine: Study of zinc, Copper and Magnesium Nanoparticles.

Rec. Pharm. Biomed. Sci. 8 (3), 109-120, 2024

Hammadi M, Derouiche S. A study on the prevalence and risk factors of coronary artery disease in

patients with metabolic syndrome infected and not infected with COVID 19 from El- Oued (Algeria) region Biomedicine: 2024; 44(1): 89-95. DOI: https://doi.org/10.51248/.v44i1.4123

Derouiche S, Abid A, Tahraoui1 ME. ROC analyses of Plasma oxidative stress markers for

Prediction of CKD complications of type 2 Diabetes. J Diabetes Endocrinol Res. 2024; 5(1):1-7.

Ahlem Frahtia, Samir Derouiche, and JanettaNiemann. GC-MS Analysis and Quantification of Some Secondary Metabolites of the Algerian Phragmites australis Leaf Extract and Their Biological Activities. Current Trends in Biotechnology and Pharmacy. 2024; 18(4) 2024-

2035,

Frahtia AHLEM , Samir DEROUICHE , Islam BOULAARES, Janetta NIEMANN, Eshak ZOLKAPLI , Nur Fathiah Mohd RADZI, Htet Htet KYAW, Hussein A. YOUNUS, Mohammed AL‑ABRI. Biosynthesis of CuNP Using Phragmites australis Rhizomes: Biological Activity and Cytotoxicity Against MCF-7 Cell Line . Lat. Am. J. Pharm. 44 (3):

223-7 (2025).

Islam Boulaares, Samir Derouiche, Janetta Niemann Phytochemical, GC-MS Analysis and Acute Toxicity Evaluation of Algerian Ocimum basilicum L in Rats. Current Trends in Biotechnology and Pharmacy . 2025 ; 19(1) 2130-2143, DOI: 10.5530/ctbp.2025.1.3

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Biodiversity and Application of Biotechnology in Agriculture